PROTEOMIC INSIGHTS INTO EXTRACELLULAR VESICLES IN ALS FOR THERAPEUTIC POTENTIAL OF ROPINIROLE AND BIOMARKER DISCOVERY

Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery

Abstract Background Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers.Notably, the comparative and longitudinal alterations in the protein profiles of EVs in serum (sEVs) and cerebrospinal fluid (CSF; cEVs) of sporadic ALS (SALS) patients remain uncharted.

read more



Characterisation of the transcriptomes of genetically diverse Listeria monocytogenes exposed to hyperosmotic and low temperature conditions reveal global stress-adaptation mechanisms.

The ability of Listeria monocytogenes to adapt to various food and food- processing environments has been attributed to its viqua-f4 robustness, persistence and prevalence in the food supply chain.To improve the present understanding of molecular mechanisms involved in hyperosmotic and low-temperature stress adaptation of L.monocytogenes, we undert

read more